CFH, ELOVL4, PLEKHA1, and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses
نویسندگان
چکیده
منابع مشابه
CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses.
Age-related maculopathy (ARM) is an important cause of visual impairment in the elderly population. It is of crucial importance to identify genetic factors and their interactions with environmental exposures for this disorder. This study was aimed at investigating the CFH, ELOVL4, PLEKHA1 and LOC387715 genes in independent cohorts collected using different ascertainment schemes. The study used ...
متن کاملC2 and CFB Genes in Age-Related Maculopathy and Joint Action with CFH and LOC387715 Genes
BACKGROUND Age-related maculopathy (ARM) is a common cause of visual impairment in the elderly populations of industrialized countries and significantly affects the quality of life of those suffering from the disease. Variants within two genes, the complement factor H (CFH) and the poorly characterized LOC387715 (ARMS2), are widely recognized as ARM risk factors. CFH is important in regulation ...
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15 صفحه اولPLEKHA1-LOC387715-HTRA1 polymorphisms and exudative age-related macular degeneration in the French population.
PURPOSE Identification of genetic factors for age-related macular degeneration (AMD) is of crucial importance in this common cause of blindness. Exudative AMD is rapidly progressive and usually associated with severe prognosis. Our purpose was to investigate this association on locus 10q26 in a case-control study including French patients specifically affected with exudative AMD. METHODS Poly...
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ژورنال
عنوان ژورنال: American Journal of Ophthalmology
سال: 2007
ISSN: 0002-9394
DOI: 10.1016/j.ajo.2007.02.012